abstract：OBJECTIVE:To assess the association between serum prostate-specific antigen (PSA) level and age, liver function tests (LFTs) including alkaline phosphatase (ALP), total bilirubin (TB), lipid profile (total cholesterol, TC, triglycerides, TG, high-density lipoprotein, HDL) and fasting blood sugar (FBS), and to determine...

journal_title：BJU international

authors： Han JH,Chang IH,Ahn SH,Kwon OJ,Bang SH,Choi NY,Park SW,Myung SC,Kim HW

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVES:To examine the results of open partial nephrectomy (OPN) over a 15-year period in a large UK teaching hospital and to compare results with other series including minimally invasive techniques, as nephron-sparing techniques are still under-utilized in the surgical treatment of renal carcinoma. A standardized ...

journal_title：BJU international

authors： Young JG,Luscombe CJ,Lynch C,Wallace DM

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVE:To investigate the antitumour effect of electroporation (EP), a drug delivery system that has been shown to be effective synergistically with antitumour drugs, with bleomycin on the growth of prostate cancer xenografts in nude mice. MATERIALS AND METHODS:PC-3 cells were implanted subcutaneously into nude mic...

journal_title：BJU international

authors： Ueki T,Uemura H,Nagashima Y,Ohta S,Ishiguro H,Kubota Y

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVES:To assess the utility of perceived control over ejaculation ('control') in the evaluation of treatment benefit in men with premature ejaculation (PE), and to compare effects associated with a two-category or greater increase in this variable between men receiving dapoxetine and placebo. PATIENTS AND METHODS...

journal_title：BJU international

authors： Shabsigh R,Patrick DL,Rowland DL,Bull SA,Tesfaye F,Rothman M

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:To develop a rat model of erectile dysfunction (ED) after cavernous nerve injury. MATERIALS AND METHODS:Given the great similarity between the anatomical structure of the cavernous nerve in rats and humans, 24 rats underwent dissections and the cavernous nerves were identified with the aid of an operating mi...

journal_title：BJU international

authors： Kaufmann O,Claro J,Cury J,Andrade E,Longo B,Aguiar W,Mello L,Srougi M

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:To assess the risk factors for haemorrhage and renal fracture associated with renal cryoablation. MATERIALS AND METHODS:In a porcine model, 120 cryoablations were administered in 26 pigs, with five groups of 24 ice-balls each; in groups 1 and 2 asynchronous cryoprobe activation was evaluated for the 1.47- an...

journal_title：BJU international

authors： Hruby G,Edelstein A,Karpf J,Durak E,Phillips C,Lehman D,Landman J

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:To examine the tissue expression of DNA topoisomerase I (Topo I) and IIalpha (Topo II), to pursue the possibility of future chemotherapy regimens for squamous cell carcinoma of the penis (SCCP), as high expression of Topo I might indicate sensitivity to the camptothecins, whereas high Topo II might indicate s...

journal_title：BJU international

authors： Berney DM,Stankiewicz E,Adlan AM,Kudahetti S,Biedrzycki OJ,Hadway P,Watkin N,Corbishley C

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:To examine whether gene profiles can provide a molecular evaluation of the quality and therapeutic potential in patients with myelomeningocele (MM), by comparing genetic profiles of smooth muscle cells (SMCs) from healthy bladders and bladders from patients, to identify genes that are over- and under-expresse...

journal_title：BJU international

authors： Hipp JA,Hipp JD,Yoo JJ,Atala A,Andersson KE

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:To study the role of peroperative transrectal ultrasonography (peTRUS) for the dissection of the bladder neck during robot-assisted laparoscopic prostatectomy (RALP). PATIENTS AND METHODS:Integrated peTRUS in the da Vinci S system (Intuitive Surgical, Sunnyvale, CA, USA) was used for bladder neck identificat...

journal_title：BJU international

authors： van der Poel HG,de Blok W,Bex A,Meinhardt W,Horenblas S

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:To assess the potentiation of erectile responses induced by electrical stimulation (ES) of the dorsal penile nerve (DPN) in the urethane-anaesthetized rat by the selective melanocortin receptor 4 agonist MB243. MATERIALS AND METHODS:Intracavernosal and blood pressures (ICP and BP, respectively) were monitore...

journal_title：BJU international

authors： Allard J,Reynolds DS,Edmunds NJ

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:To investigate the feasibility and clinical outcome of extracorporeal shock-wave therapy (ESWT) for patients suffering from chronic pelvic pain syndrome (CPPS). PATIENTS AND METHODS:The study included 34 patients who had had CPPS for >or=3 months, who were investigated in two subsequent studies. ESWT was adm...

journal_title：BJU international

authors： Zimmermann R,Cumpanas A,Hoeltl L,Janetschek G,Stenzl A,Miclea F

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVES:To examine the feasibility of using laser energy during nerve-sparing robotically assisted radical prostatectomy (RARP), as the energy sources currently used for haemostasis in RARP adversely affect cavernous nerve function, while clips require application by a skilled assistant, but laser energy potentially...

journal_title：BJU international

authors： Gianduzzo T,Colombo JR Jr,Haber GP,Hafron J,Magi-Galluzzi C,Aron M,Gill IS,Kaouk JH

更新日期：2008-08-05 00:00:00

abstract：OBJECTIVE:To determine the value of gene-expression profiling as a predictor of the status of the regional nodes in patients with penile carcinoma. PATIENTS AND METHODS:Tumour samples of 56 patients with penile squamous cell carcinoma were analysed for the gene expression on 35 k oligoarrays; 32 were from patients wit...

journal_title：BJU international

authors： Kroon BK,Leijte JA,van Boven H,Wessels LF,Velds A,Horenblas S,van't Veer LJ

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:To investigate the feasibility of transcript profiling in diagnostic formalin-fixed and paraffin-embedded (FFPE) biopsies for prostate cancer. MATERIALS AND METHODS:Laser-capture microdissection (LCM) was used to microdissect glandular epithelium as well as stromal tissue in archival prostate needle biopsies...

journal_title：BJU international

authors： Rogerson L,Darby S,Jabbar T,Mathers ME,Leung HY,Robson CN,Sahadevan K,O'Toole K,Gnanapragasam VJ

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:To determine the role of hypoxia-inducible factor-2alpha (HIF2alpha) on the sensitivity of renal cell carcinoma (RCC) cell lines to ionizing radiation and to determine if the mTOR antagonist, rapamycin, could decrease HIF2alpha protein levels. MATERIALS AND METHODS:Cell lines expressing stable short-hairpin ...

journal_title：BJU international

authors： Bhatt RS,Landis DM,Zimmer M,Torregrossa J,Chen S,Sukhatme VP,Iliopoulos O,Balk S,Bubley GJ

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVES:To assess atypical cytology as a positive bladder tumour marker and to determine if indexing atypical cytology to nuclear matrix protein-22 (NMP22) can decrease the false-positive results or increase the positive predictive value (PPV). PATIENTS AND METHODS:In all, 197 patients at risk of bladder cancer wer...

journal_title：BJU international

authors： Raina R,Pahlajani G,Ponsky LE,Agarwal A,Zippe CD

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:To report the use of a novel donor source as a further option to increase the number of patients who might be able to receive a renal transplant. PATIENTS AND METHODS:Between May 1996 and July 2007, 43 kidneys were transplanted using kidneys obtained from patients with small (<3 cm diameter) incidentally det...

journal_title：BJU international

authors： Nicol DL,Preston JM,Wall DR,Griffin AD,Campbell SB,Isbel NM,Hawley CM,Johnson DW

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:To assess the expression of the tumour markers stromelysin 3, MUC1, p53 and cytokeratin-7 in papillary renal cell carcinoma (pRCC, for which two histological subtypes are distinguished, i.e. type 1 and type 2, the latter appearing to be associated with a poorer prognosis) and to determine whether any of these...

journal_title：BJU international

authors： Perret AG,Clemencon A,Li G,Tostain J,Peoc'h M

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVES:To evaluate the relative merits of robotically assisted partial nephrectomy (RPN), using a matched-pair analysis, with laparoscopic PN (LPN). PATIENTS AND METHODS:Between July 2006 and August 2007, 12 patients had RPN for tumour; the outcomes were compared retrospectively with 12 matched patients who had LP...

journal_title：BJU international

authors： Aron M,Koenig P,Kaouk JH,Nguyen MM,Desai MM,Gill IS

更新日期：2008-07-01 00:00:00

abstract：:Accurate prediction is essential for patient counselling, appropriate selection of treatments and determination of eligibility for clinical trials. In this review we assess the available determinants of oncological outcome after radical cystectomy (RC) for transitional cell carcinoma of the urinary bladder. We reviewe...

journal_title：BJU international

authors： Margulis V,Lotan Y,Montorsi F,Shariat SF

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:To present our initial experience in children undergoing single-port laparoscopic varicocelectomy (SPLV) using a new approach in which the entire procedure is performed through a multichannel single laparoscopic port inserted in the umbilicus rather than the traditional LV performed through three abdominal po...

journal_title：BJU international

authors： Kaouk JH,Palmer JS

更新日期：2008-07-01 00:00:00

abstract：:In the last 3 years there has been a dramatic increase in the treatment options for patients with metastatic renal cancer. In addition to the cytokines interferon and interleukin 2, recently approved agents include sorafenib, sunitinib, temsirolimus and bevacizumab. A plethora of agents that are likely to have clinica...

journal_title：BJU international

authors： Samlowski WE,Wong B,Vogelzang NJ

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:To report our experience of 11 children with pelvi-ureteric junction obstruction (PUJO) in a duplex kidney and to review previous reports. PATIENTS AND METHODS:From 1995 to 2005 the second author (G.H.H.S.) performed 145 pyeloplasties in single-system kidneys and in 11 children with PUJO in a duplex kidney. ...

journal_title：BJU international

authors： Horst M,Smith GH

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:To characterize the clinicopathological findings and the outcome of human immunodeficiency virus (HIV)-infected patients diagnosed and treated for prostate carcinoma, as HIV-positive men being treated with highly active antiretroviral therapy (HAART) are living longer and thus are more likely to develop cance...

journal_title：BJU international

authors： Pantanowitz L,Bohac G,Cooley TP,Aboulafia D,Dezube BJ

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVES:To evaluate the impact of different risk factors and symptoms on the performance characteristics of the nuclear matrix protein 22 (NMP22) BladderChek test (Matritech Inc., Newton, MA, USA) for the detection of bladder cancer, as this is a point-of-care assay that measures NMPs in voided urine. PATIENTS AND ...

journal_title：BJU international

authors： Lotan Y,Shariat SF,NMP22 Study Group.

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the association between the International Prostate Symptom Score (IPSS) bother question (BQ) and a validated disease-specific quality-of-life questionnaire, the Benign Prostatic Hyperplasia (BPH) Impact Index (BPH-II), using the BPH Registry and Patient Survey database. PATIENTS AND METHODS:The B...

journal_title：BJU international

authors： O'Leary MP,Wei JT,Roehrborn CG,Miner M,BPH Registry and Patient Survey Steering Committee.

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:To investigate the prevalence of asymptomatic bacteriuria (ABU) and urinary tract infection (UTI), and the local and systemic inflammatory response, in patients with ileal neobladder. PATIENTS AND METHODS:The study included 40 patients who had a radical cystectomy and ileal neobladder. Two urine samples, one...

journal_title：BJU international

authors： Suriano F,Gallucci M,Flammia GP,Musco S,Alcini A,Imbalzano G,Dicuonzo G

更新日期：2008-06-01 00:00:00

abstract：:Tribute to Professor Pieter De Mulder, from Martin Gore. Pieter and I were often pitted against each other in debates at international meetings on the role of cytokine therapy. The truth is that there was little disagreement between us, but we both thought such set pieces were a good way to highlight the issues surrou...

journal_title：BJU international

authors： Gore ME,De Mulder P

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:To assess whether under- or overweight at the time of surgery has any effect on the survival of the patients with renal cell carcinoma (RCC), as obesity increases the risk of developing RCC. PATIENTS AND METHODS:We prospectively evaluated 780 patients who had nephrectomy for RCC between 1990 and 2005. We use...

journal_title：BJU international

authors： Haferkamp A,Pritsch M,Bedke J,Wagener N,Pfitzenmaier J,Buse S,Hohenfellner M

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVES:To evaluate whether robotically assisted laparoscopic prostatectomy (RALP) is less invasive than radical retropubic prostatectomy (RRP), as experimental studies suggest that the acute phase reaction is proportional to surgery-induced tissue damage. PATIENTS AND METHODS:Between May and November 2006, all pat...

journal_title：BJU international

authors： Fracalanza S,Ficarra V,Cavalleri S,Galfano A,Novara G,Mangano A,Plebani M,Artibani W

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:To test the replicability and robustness of findings about urological symptoms in men and women, classified using an objective statistical method, cluster analysis, by planned sensitivity analyses conducted within and across two large, epidemiological studies of lower urinary tract symptoms. METHODS:Sensitiv...

journal_title：BJU international

authors： Rosen RC,Coyne KS,Henry D,Link CL,Cinar A,Aiyer LP,Mollon P,Kaplan SA,Roehrborn CG,Thompson C

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:To assess the long-term outcome of forearm free-flap phalloplasty in transsexuals, as obtaining a satisfying neophallus in female-to-male transsexuals is a surgical challenge. PATIENTS AND METHODS:We analysed retrospectively 56 transsexuals who had a phalloplasty using a radial forearm free-flap in our depar...

journal_title：BJU international

authors： Leriche A,Timsit MO,Morel-Journel N,Bouillot A,Dembele D,Ruffion A

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:To determine the changes in body composition, muscle function and energy expenditure after radical cystectomy (RC). PATIENTS AND METHODS:Eleven consecutive men (median age 66 years, range 44-79) who had a RC over a 1-year period had measurements made of their total body protein, by neutron-activation analysi...

journal_title：BJU international

authors： Mathur S,Plank LD,Hill AG,Rice MA,Hill GL

更新日期：2008-04-01 00:00:00

abstract：:For the delivery of good-quality external beam radiotherapy (EBRT) in localized prostate cancer, under-dosage to the peripheral zone (tumour) is one likely cause of poor results. The quality is improved by daily verification of the position of the prostate, and the use of magnetic resonance imaging (MRI) in delineatio...

journal_title：BJU international

authors： van Vulpen M,van der Heide UA,van Moorselaar JR

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:To critically review published data on the urogynaecological aspects of female sexual dysfunction (FSD), as FSD is a developing multidisciplinary issue associated with several biological, medical and psychological factors. METHODS:The reported prevalence of FSD is 19-50% and women with lower urinary tract sy...

journal_title：BJU international

authors： Dalpiaz O,Kerschbaumer A,Mitterberger M,Pinggera GM,Colleselli D,Bartsch G,Strasser H

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:To aid the interpretation of the trends in prostate cancer mortality, which declined in the UK in the early 1990 s for unknown reasons, by investigating prostate cancer death rates, incidence and treatments in England and Wales in 1975-2004. METHODS:Join-point regression was used to assess secular trends in ...

journal_title：BJU international

authors： Hussain S,Gunnell D,Donovan J,McPhail S,Hamdy F,Neal D,Albertsen P,Verne J,Stephens P,Trotter C,Martin RM

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:To determine if FK506-binding proteins (FKBPs) are localized to the autonomic nerve supply of the human penis because FK506 (an immunosuppressant drug) has been linked to enhanced nerve regeneration after nerve injury and neurodegenerative diseases by binding to FKBPs, a select group of immunophilins. MATERI...

journal_title：BJU international

authors： Lagoda G,Sezen SF,Liu T,Höke A,Burnett AL

更新日期：2008-03-01 00:00:00

abstract：:Category III chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is the most commonly diagnosed prostatitis syndrome. CP/CPPS is characterized by lower urinary tract symptoms (LUTS) of which pain (particularly perineal pain and pain on ejaculation) and dysfunctional voiding cause the greatest morbidity and poor...

journal_title：BJU international

authors： Nickel JC

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of prostate weight on perioperative, functional and oncological outcomes after laparoscopic radical prostatectomy (LRP). PATIENTS AND METHODS:Between January 2003 and January 2006, 327 patients had LRP by one surgeon, 193 of whom were available for analysis. Patients were stratified in...

journal_title：BJU international

authors： Frota R,Turna B,Santos BM,Lin YC,Gill IS,Aron M

更新日期：2008-03-01 00:00:00

abstract：:The introduction of prostate-specific antigen (PSA) has revolutionized the detection and management of patients with prostate cancer. Despite this there has always been a concern among clinicians about the usefulness of total PSA levels as a marker for prostate cancer. We discuss the use of calculated variables and mo...

journal_title：BJU international

authors： Shariat SF,Karam JA,Margulis V,Karakiewicz PI

更新日期：2008-03-01 00:00:00